Tag: (S)-Equol

What is the regulatory status of (S)-equol abroad? In which countries can it be used?

(1) Canada In medicinal applications, S-Equol is recognized as a Natural Health Product (NHP) and is classified under Schedule 1, Item 2 (an isolate) of the Natural Health Products Regulations. In non-medicinal applications, it is used as a skin conditioning agent, restricted to topical application. (2) United States (S)-equol has not been directly included in
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What is the proof that (S)-equol is safe for consumption? What are the safety data?

Acute toxicity test LD50 > 2000 mg/kg (rats), classified as practically non-toxic Subchronic/chronic toxicity 90-day rat feeding study showed a NOAEL (No Observed Adverse Effect Level) of 300 mg/kg/day Reproductive toxicity Non-teratogenic, non-embryotoxic (OECD standard tests) Genotoxicity Ames test, micronucleus test, and chromosome aberration test were all negative Human clinical trials Multiple RCT studies show
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(S)-Equol Is there a risk of introducing estrogens through soybean fermentation? Will it introduce other phytoestrogens?

Is there a risk of introducing estrogens through soybean fermentation? Will it introduce other phytoestrogens? Instead of directly fermenting soybeans, daidzein is used as the raw material for fermentation. (1) Neither the fermentation raw materials nor the production process contains animal estrogens, meaning there is no risk of their introduction. (2) Since the raw material
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What is the solubility of (S)-equol?

Property Category Details Water Solubility Low; it is a fat-soluble compound. Under weakly alkaline conditions (e.g., pH > 8), it can dissociate to form phenolate ions, leading to an increase in solubility. Solubility in Organic Solvents Freely soluble: Ethanol, methanol, DMSO (dimethyl sulfoxide) Slightly soluble: Ethyl acetate, acetone Practically insoluble: Non-polar solvents such as n-hexane
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