What is the proof that (S)-equol is safe for consumption? What are the safety data?
Acute toxicity test LD50 > 2000 mg/kg (rats), classified as practically non-toxic Subchronic/chronic toxicity 90-day rat feeding study showed a NOAEL (No Observed Adverse Effect Level) of 300 mg/kg/day Reproductive toxicity Non-teratogenic, non-embryotoxic (OECD standard tests) Genotoxicity Ames test, micronucleus test, and chromosome aberration test were all negative Human clinical trials Multiple RCT studies show